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Sunday heralds the initial Wear-Tyne derby since 2024, but which side will celebrate – the Black Cats or the Magpies?
"Throughout the majority of last season, no one would have predicted the Wearside club getting promoted and holding their own with Eddie Howe's Newcastle, never mind being above them in the table," commented pundit Chris Sutton.
"The situation is very different now, and the way they play leads me to believe they've got a genuine opportunity."
Sutton is making forecasts for all 380 Premier League games this season, in competition with AI, the public and a range of guests.
For this weekend's fixtures, he is challenged by England Gaming star Daniel 'Stingray' Ray.
Ray is going for glory for the national gaming squad – the Football Association's official esports team – at the football simulation digital Euros finals tournament, which is being held at Twickenham Stadium on Saturday.
Viewers can catch Uefa's video platform, IG Live and short-form video channels, as well as the official Twitch channel and YouTube and the national team's Twitch.
Do you agree with their forecasts? Share your own guesses below.
The most popular scoreline selected for each game is used in the leaderboards at the end of this page.
Predicting the right outcome (selecting a win, draw or defeat) is worth 10 points. A perfect prediction earns forty points.
Ray, who competes for Gen City and the Premier League champions as well as England, is competing for the first time at the eEuros finals after successfully navigating the preliminary stage.
The final eight competitors will represent their nations at the finals in a knockout format, playing for a substantial cash prize and a coveted spot in the global championship qualifiers, with Denmark's Anders Vejrgang defending the title he won last year.
"I'm feeling really good for it," Ray stated. "There's a really good coach alongside me and practice has been going well.
"It's always an honour to play for your country. Naturally when you are younger, you fantasise about doing it as an professional footballer, but when you go into this job and there is an chance to represent England, putting the shirt on is something special.
"I beat Vejrgang 9-4 in qualifying to get here. I've played against him throughout the year just in practice, and in other tournaments before - but I'd not previously defeated him in a tournament before.
"For me he is the number one in the world so beating him in a tournament like this just delivers a massive injection of confidence."
Premier League Weekend Preview
Saturday, 13 December
Chelsea vs Everton
Stamford Bridge, 15:00 GMT
The Blues were outstanding against Arsenal at the end of November, when they secured a point after being reduced to 10 men, and I was thinking they've turned a corner, they could possibly be challengers for the crown.
Since then, however, they were beaten physically by Leeds, looked flat against Bournemouth and this week got defeated by Atalanta in the Champions League.
So head coach Enzo Maresca desperately requires a win here to restore momentum, but it will be a challenge because Everton are such a dangerous team.
Two of their stars are playing really well and Everton have got a bit of momentum at the moment.
Current evidence suggests you would likely back the visitors, while the most prudent prediction would probably be a draw, but I'm throwing caution to the wind.
They have not given me any compelling evidence to back them recently, but I just have a gut instinct they will take this one because they are at home and they are overdue a victory.
Sutton's prediction: 2-1
Stingray's prediction: With this being at the Bridge, I am going to back Chelsea. I think they will start off really well and go 2-0 up, then Everton will nick one back but then Chelsea score late. 3-1
AI's prediction: 2-0
Liverpool vs Brighton
Anfield, 15:00 GMT
I'll be at this game and it will be fascinating to see what we get from the Reds.
I was delighted for Reds boss Arne Slot to get such a important victory at Inter Milan on Tuesday following all the discussion with Mohamed Salah this week.
Slot ought not to put up with that distraction. I know Salah has been a legend for Liverpool but fundamentally Slot just wants to win games and there is no ulterior motive in his team selection.
Liverpool changed their shape against Inter and went with a midfield diamond and two up top.
All the talk is going to be talking about whether Salah is selected for this game, but the only way he is going to be reintegrated is if he makes amends.
Slot's primary concern will be on winning this game, but it is a tough one.
One might suggest it is the same for most teams but I find Brighton so mercurial. I always feel they have got a goal in them, but they are quite open too.
The Merseysiders need to get back to stringing wins together, but I am not sure how much their exertions at the San Siro will have taken out of them.
I put a couple of Brighton players in my Fantasy Premier League side, so they will almost certainly blank - but I do fancy them to get something at Anfield.
Sutton's prediction: 2-2
Stingray's prediction: This is a game which is going to give Liverpool a bit more of their confidence back. Obviously they had a good win in midweek and they can build more momentum here. 2-1
AI's prediction: 3-1
Sunday, 14 December
Sunderland vs Newcastle
Stadium of Light, 14:00 GMT
Sunderland have had the benefit of a free week while Newcastle had to work so hard against Bayer Leverkusen on Wednesday, only to concede a late equaliser late on.
Aside from their superb performance against Everton a couple of weeks ago, Newcastle's away form hasn't been great, especially straight after they've played in the Champions League.
I am expecting that trend to continue on Sunday, and their lack of freshness is likely to be a key element in how this game goes because of their rivals' high press.
It was evident how unwavering Regis le Bris's side are. They overpowered the Gunners, and it was incredible to watch.
Many pundits talks about how Granit Xhaka has been outstanding for the Black Cats, and he has been superb, but Noah Sadiki, who plays next to him, has also been one of the signings of the season and deserves some attention too.
All signs point to this being the best game|most exciting fixture